from functools import reduce
lst = [Q(question_text__contains='you'), Q(question_text__contains='who')]
# OR
>>> Question.objects.filter(reduce(operator.or_, lst))
[<Question: what are you doing>, <Question: what is wrong with you>, <Question: who are you>, <Question: who am i>]
# AND
>>> Question.objects.filter(reduce(operator.and_, lst))
[<Question: who are you>]
>>> from functools import reduce
>>> reduce(lambda x, y: x + y, [1,2,3,4,5,6,7,8])
36